The actor, who makes the ITV drama with producer wife Philippa Braithwaite, warned in 2017 they may retire his character after series nine.
And he has now said he will definitely bow out with series 10, which will be filmed in Cornwall next year.
Clunes, 58, said: “We have loved making nine series of Doc Martin.
“When we launched the series in 2004 we could never have imagined how much our loyal viewers would take to the grumpy Doc like they have.”
He went on: “The series has avid fans both in the UK and throughout the world and we are thrilled that Doc Martin has topped the ratings every time.
“However, after sixteen years we now feel that the time has come to say goodbye to Portwenn. We will be making the tenth and final series in 2021 and we are very much looking forward to returning to Cornwall to film it.”
Men Behaving Badly star Clunes said in 2017: “In 2019 we’ll do season 9, and that – as far as we know – is it. We may have to retire the doctor. He’ll probably be of retirement age by then.”
In the drama, Clunes plays a gruff GP who used to be a surgeon – but had to quit as he could not stand the sight of blood.
He eventually weds on-off girlfriend Louisa, played by Caroline Catz.
Protests against racial inequality and police brutality continued across the country on Sunday night
Demonstrators confronted restaurant diners in Pittsburgh, downing their drinks and smashing glasses
In Rochester, New York, a man was struck by a vehicle during a demonstration over the death of Daniel Prude
In Portland 59 people were arrested overnight Saturday – setting a record for protest-related arrests so far
Black Lives Matter protesters screamed in the face of white elderly outdoor diners during protests in Pittsburgh on Saturday, disturbing new video shows.
Cellphone footage shows the crowd taking over the outdoor dining space with one person even approaching the older couple’s table before drinking their beer in front of them; another smashed a glass from a table.
One protester tells the diners: ‘Fuck the white people that built the system.’ He adds: ‘Fuck 12′; a reference to police. Others eating at the restaurant pick up their belonging and leave after demonstrators call them an ’embarrassment’.
The demonstrations are in response to several black Americans who have died in police custody, with the recently shared footage of the death of Daniel Prude in Rochester, New York in March, sparking the new wave of outrage.
Similar scenes have played out across the county with a diner in Washington D.C. last week cornered by a group of anti-racism protesters outside a restaurant. In another incident, diners in Rochester were also confronted by a large group of demonstrators.
‘We’re shutting your party down,’ one woman was seen shouting in the face of a New York diner as demonstrators smashed the customer’s glasses in front of their faces, broke plates, overturned chairs and chanted at them to get out.
A second video taken in Pittsburgh over the weekend shows a demonstrator speaking with a megaphone while walking next to a cyclist. It’s unclear what is said, but the demonstrator nudges the cyclist with his megaphone. The cyclist swats the demonstrator in response, but a second protester hits the man from behind.
Police in Pittsburgh are said to have launched an investigation into both clips; there were no arrests during Saturday’s protest.
Black Lives Matter protesters screamed in the face of white elderly outdoor diners during protests in Pittsburgh on Saturday, disturbing new video shows
When demonstrators entered the outdoor dining space, one person took a couples’ drink and drank it herself before leaving
Beauty influencer Ethan Peters (aka Ethan Is Supreme) has died at 17 years old, following an apparent drug overdose.
Although details are scarce, he appears to have overdosed (possibly on Percocet) over the weekend.
Peters’ friend and fellow influencer Ava Louise took to Twitter on Saturday to break the news of her confidante’s passing, explaining that he’d developed a drug dependency in recent years.
RIP: Beauty influencer Ethan Peters (aka Ethan Is Supreme) has died at 17 years old, following an apparent drug overdose
She posted a throwback photo of them, writing: ‘My best friend in the entire world, my twin flame…..the only person there for me when I had no one.
‘I love you Ethan, I am at a loss for words. I wish I knew how bad it was. I know what you’d want me to say to the Internet rn but I’m to heartbroken to say it. Rip’
Louise continued: ‘Addiction is a disease. I had to pull Ethan aside in recent weeks and have talks with him about his usage.
‘Everyone close to him was scared. I just wish I fucking tried harder I fucking wish I yelled at him more I wish I didn’t enable a single pill he popped.’
Tragic passing: Although details are scarce, he appears to have overdosed (possibly on Percocet) over the weekend
Gone too soon: Peters was a rising influencer, with more than 500k Instagram followers
She also claimed: ‘2 percs killed my best friend. ONLY 2. Don’t do them or if you wanna at least fucking test them first. Be safe- you don’t want your best friend to feel what I feel right now.’
Louise added: ‘Ethan was well liked and well respected in the beauty industry. About a year ago he turned to drugs due to the pressure of being famous online at such a young age.
‘He became problematic recently due to drug induced mania. He’s a good fucking person. He didn’t deserve to die.’
The influencer also took to Twitter with some resources for others struggling with addiction.
She wrote: ‘Ethan had an addiction and addiction should not be shamed. I’m openly discussing his cause of death to save the next kid from a perc.
Breaking news: Peters’ friend and fellow influencer Ava Louise took to Twitter on Saturday to break the news of her confidante’s passing, explaining that he’d developed a drug dependency in recent years
Paying respects: Other friends like Manny MUA also paid their respects
‘He was so bright and so smart. He needed to live. He was more than his demons and you all are to. Please get help. Call 1-800-662-4357’
Other friends like Manny MUA also paid their respects, writing on Twitter: ‘rest in peace ethan @trashqueenethan you were so incredibly talented at such a young age.
‘i know he’s made many many mistakes… but to say he deserved to pass away is horrible and inhuman. i pray for his family and loved ones, a horrible loss’
Tana Mongeau posted a throwback to her Instagram Story with Peters, writing: ‘rip angel. my heart goes out to his family and friends. if you need anything reach out please.’
Grace Anne Auten also took to Instagram with some beach photos of the two of them, writing: ‘I love you. I can’t believe I have to say goodbye so soon.
‘We just talked a couple days ago, when you sent me a video of the disposables that had just come in from your visit here. F***. I f***ing hate it here. I wish I could say more..but there just aren’t any words. I love you. I believe you’re still here for me.’
Only two: Louise claimed on Twitter: ‘2 percs killed my best friend. ONLY 2. Don’t do them or if you wanna at least fucking test them first. Be safe- you don’t want your best friend to feel what I feel right now’